LOUISVILLE, Ky. — University of Louisville research could help spur new medicines by extending the usable life of test heart tissue from one day to 12. The findings were published in the journal Nature – Communications Biology.
Biomedical researchers use slices of heart tissue to test the effectiveness and toxicity of new drugs, drug candidates and gene therapies. Until recently, those slices’ limited, 24-hour usable life created a major barrier to drug discovery, slowing the development of new, potentially life-saving medications.
UofL methods, developed by a multidisciplinary team from the School of Medicine and J.B. Speed School of Engineering, extended the tissue’s usable life first to six days with a discovery in 2019 and now to 12 days by mimicking the conditions experienced by a living heart. The tissue ‘lives’ in a pneumatic chamber, receiving
Because of the short shelf-life of human heart tissue, many drug candidates today are tested in ways that poorly emulate living heart tissue or use tests that otherwise don’t show the full range of potential side effects related to cardiotoxicity. This causes some drug candidates to fail Phase 1 clinical trials or, worse, be taken off the market after being launched for clinical use. The UofL team believes their method can help solve this problem, potentially leading to better, safer medications.
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